KU-0058948

• CAT Number: R056186
• CAS Number: 763111-49-5
• Molecular Formula: C₂₁H₂₁FN₄O₂
• Molecular Weight: 380.42
• Purity: ≥95%
• Synonyms: 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone; KU 0058948; KU0058948; 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine
• Storage: -20°C
• InChI: 1S/C21H21FN4O2/c22-18-7-6-14(12-17(18)21(28)26-10-3-8-23-9-11-26)13-19-15-4-1-2-5-16(15)20(27)25-24-19/h1-2,4-7,12,23H,3,8-11,13H2,(H,25,27)
• InChIKey: HGEPGGJUGUMFHT-UHFFFAOYSA-N
• SMILES: C1CNCCN(C1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F

KU-0058948 is a potent and selective inhibitor of poly (ADP-ribose) polymerase (PARP), a key enzyme involved in DNA repair. By inhibiting PARP activity, KU-0058948 enhances the accumulation of DNA damage, particularly in cancer cells with defective homologous recombination repair, such as those with BRCA mutations. This makes it a valuable agent in cancer therapy, particularly for targeting tumors with inherent vulnerabilities in DNA repair pathways. It has shown promising results in preclinical studies for its potential to sensitize tumors to chemotherapy and radiotherapy, positioning it as a critical tool in targeted cancer treatment strategies.