KU-60019

• CAT Number: I005509
• CAS Number: 925701-46-8
• Molecular Formula: C30H33N3O5S
• Molecular Weight: 547.67
• Purity: ≥95%
• Synonyms: KU60019
• Target: ATM
• Solubility: DMSO: ≥ 30 mg/mL
• Storage: -20°C
• IC50: 6.3 nM
• IUPAC Name: 2-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-N-[5-(6-morpholin-4-yl-4-oxopyran-2-yl)-9H-thioxanthen-2-yl]acetamide
• InChI: InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
• InChIKey: SCELLOWTHJGVIC-BGYRXZFFSA-N
• SMILES: CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6

KU-60019（Cat No.:I005509）is a potent and selective inhibitor of ataxia-telangiectasia mutated (ATM) kinase, a key player in the DNA damage response pathway. By blocking ATM activity, KU-60019 impairs the repair of DNA double-strand breaks, enhancing the sensitivity of cancer cells to radiation and chemotherapy. This compound is widely used in cancer research to investigate DNA repair mechanisms and the role of ATM in tumor survival. Its ability to potentiate the effects of DNA-damaging treatments makes KU-60019 a valuable tool in developing novel cancer therapies.

Reference

[1]. Golding SE et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.


[2]. Golding SE, Rosenberg E, Adams BR, Wignarajah S, Beckta JM, O/’Connor MJ, Valerie K.Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control.Cell Cycle. 2012 Mar 15;11(6):1167-73. Epub 2012 Mar 15.


[3]. Raso A, Vecchio D, Cappelli E, Ropolo M, Poggi A, Nozza P, Biassoni R, Mascelli S, Capra V, Kalfas F, Severi P, Frosina G.Characterization of Glioma Stem Cells Through Multiple Stem Cell Markers and Their Specific Sensitization to Double-Strand Break-Inducing Agents by Pharmacological Inhibition of Ataxia Telangiectasia Mutated Protein.Brain Pathol. 2012 Sep;22(5):677-688.