For research use only. Not for therapeutic Use.
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively[1][2].
| Catalog Number | R039637 |
| CAS Number | 254886-77-6 |
| Synonyms | (2R,3R)-2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one |
| Molecular Formula | C25H28O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H28O7/c1-12(2)5-6-14(13(3)4)9-17-19(28)11-20(29)21-22(30)23(31)25(32-24(17)21)16-8-7-15(26)10-18(16)27/h5,7-8,10-11,14,23,25-29,31H,3,6,9H2,1-2,4H3/t14-,23+,25-/m1/s1 |
| InChIKey | ZJRPDIPXWGIHRB-HVVPNVAPSA-N |
| SMILES | CC(=CCC(CC1=C2C(=C(C=C1O)O)C(=O)C(C(O2)C3=C(C=C(C=C3)O)O)O)C(=C)C)C |
| Reference | [1]. Cheng-Peng Sun, et al. The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase. Int J Biol Macromol. 2020 Jan 15;143:349-358. [2]. Sha-Sha Song, et al. Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations. Int J Biol Macromol. 2019 Jun 15;131:201-208. |
