Kv1.3 Channel blocker 42

• CAT Number: I047560
• CAS Number: 2108780-57-8
• Molecular Formula: C28H35FN2O4.HCl
• Molecular Weight: 519.05
• Purity: ≥95%
• IUPAC Name: 1-[7-[3-(4-fluorophenyl)butoxy]-2,4-dimethyl-6-(2-piperidin-1-ylethoxy)-1,3-benzoxazol-5-yl]ethanone;hydrochloride
• InChI: InChI=1S/C28H35FN2O4.ClH/c1-18(22-8-10-23(29)11-9-22)12-16-33-28-26(34-17-15-31-13-6-5-7-14-31)24(20(3)32)19(2)25-27(28)35-21(4)30-25;/h8-11,18H,5-7,12-17H2,1-4H3;1H
• SMILES: CC1=C(C(=C(C2=C1N=C(O2)C)OCCC(C)C3=CC=C(C=C3)F)OCCN4CCCCC4)C(=O)C.Cl

Potassium channel blocker, selective in blocking the Kv1.3 current (IC50: <50 nM); Selectivity: 25-fold over Kv1.1 and 24-fold over Kv1.5

Reference

AJ Harvey et al. Novel potassium channel blockers and uses thereof. Patent BIONOMICS LTD. WO2009149508 (A1)