For research use only, not for therapeutic use.
KW-2449 hydrochloride (Cat No.:I000066) is a multi-targeted inhibitor with a strong affinity for FMS-like tyrosine kinase 3 (Flt3) with an IC50 of 6.6 nM. It also exhibits moderate potency against fibroblast growth factor receptor 1 (FGFR1), Bcr-Abl, and Aurora A kinases. However, it has little effect on platelet-derived growth factor receptor beta (PDGFRβ), insulin-like growth factor-1 receptor (IGF-1R), and epidermal growth factor receptor (EGFR). The broad spectrum of kinase inhibition suggests potential applications of KW-2449 in targeting multiple signaling pathways implicated in various diseases, including cancer.
| Catalog Number | I000066 |
| CAS Number | 1000669-72-6 |
| Synonyms | [4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone |
| Molecular Formula | C20H20N4O. HCl |
| Purity | ≥95% |
| Target | FLT3 |
| Solubility | DMSO ≥63mg/mL Water <1.2mg/mL Ethanol ≥63mg/mL |
| Storage | 3 years -20C powder |
| Overview of Clinical Research | KW-2449 is an aurora kinase inhibitor , a Bcr-abl tyrosine kinase inhibitor, and a Fms-like tyrosine kinase 3 inhibitor. It is to treat acute myeloid leukaemia. |
| IC50 | 6.6 nM |
| IUPAC Name | [4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone |
| InChI | InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ |
| InChIKey | YYLKKYCXAOBSRM-JXMROGBWSA-N |
| SMILES | C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43 |
| Reference | <br /> |
