For research use only. Not for therapeutic Use.
KW-2478(CAT: I007541) is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. HSP90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses.
| Catalog Number | I007541 |
| CAS Number | 819812-04-9 |
| Synonyms | KW2478; KW-2478; KW 2478.;2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide |
| Molecular Formula | C30H42N2O9 |
| Purity | ≥95% |
| Target | HSP |
| Solubility | Soluble in DMSO, not soluble in water. |
| Storage | 3 years -20C powder |
| Related CAS | 819812-18-5(hydrochloride) |
| IUPAC Name | 2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide |
| InChI | InChI=1S/C30H42N2O9/c1-5-22-23(19-28(35)32(11-13-37-2)12-14-38-3)29(25(34)20-24(22)33)30(36)21-6-7-26(27(18-21)39-4)41-17-10-31-8-15-40-16-9-31/h6-7,18,20,33-34H,5,8-17,19H2,1-4H3 |
| InChIKey | VFUXSYAXEKYYMB-UHFFFAOYSA-N |
| SMILES | CCC1=C(C=C(C(=C1CC(=O)N(CCOC)CCOC)C(=O)C2=CC(=C(C=C2)OCCN3CCOCC3)OC)O)O |
| Reference | 1: Yong K, Cavet J, Johnson P, Morgan G, Williams C, Nakashima D, Akinaga S, <br> <br> |
