KWAR 23

• CAT Number: I043208
• CAS Number: 2243227-60-1
• Purity: ≥95%

KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research[1].
KWAR 23 (0-1 μM; 4 h) shows antitumor activity of human neutrophil and macrophage[1].
KWAR 23 induces human macrophage-dependent phagocytosis in human tumor-derived cell lines[1].
KWAR23 (intraperitoneal injection; 10 mg/kg; every other day; 21 d) exhibits effective antitumor activity in a human SIRPA knockin mouse model[1].
KWAR23 enhances neutrophil and macrophage antitumor activity in SRG Mice[1].

Reference

[1]. Ring NG, et al. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10578-E10585.
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