KY1220

For research use only. Not for therapeutic Use.

  • CAT Number: I013212
  • CAS Number: 292168-79-7
  • Molecular Formula: C₁₄H₁₀N₄O₃S
  • Molecular Weight: 314.32
  • Purity: ≥95%
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KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.


Catalog Number I013212
CAS Number 292168-79-7
Molecular Formula C₁₄H₁₀N₄O₃S
Purity ≥95%
Target Wnt β-catenin
Solubility DMSO: ≥100 mg/mL
IUPAC Name (5Z)-5-[[1-(4-nitrophenyl)pyrrol-2-yl]methylidene]-2-sulfanylideneimidazolidin-4-one
InChI InChI=1S/C14H10N4O3S/c19-13-12(15-14(22)16-13)8-11-2-1-7-17(11)9-3-5-10(6-4-9)18(20)21/h1-8H,(H2,15,16,19,22)/b12-8-
InChIKey FMLUAKSJMUPACD-WQLSENKSSA-N
SMILES C1=CN(C(=C1)C=C2C(=O)NC(=S)N2)C3=CC=C(C=C3)[N+](=O)[O-]
Reference

[1]. Cha PH, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600.

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