For research use only. Not for therapeutic Use.
KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.
Catalog Number | I013212 |
CAS Number | 292168-79-7 |
Molecular Formula | C₁₄H₁₀N₄O₃S |
Purity | ≥95% |
Target | Wnt β-catenin |
Solubility | DMSO: ≥100 mg/mL |
IUPAC Name | (5Z)-5-[[1-(4-nitrophenyl)pyrrol-2-yl]methylidene]-2-sulfanylideneimidazolidin-4-one |
InChI | InChI=1S/C14H10N4O3S/c19-13-12(15-14(22)16-13)8-11-2-1-7-17(11)9-3-5-10(6-4-9)18(20)21/h1-8H,(H2,15,16,19,22)/b12-8- |
InChIKey | FMLUAKSJMUPACD-WQLSENKSSA-N |
SMILES | C1=CN(C(=C1)C=C2C(=O)NC(=S)N2)C3=CC=C(C=C3)[N+](=O)[O-] |
Reference | [1]. Cha PH, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600. |