KY1220

• CAT Number: I013212
• CAS Number: 292168-79-7
• Molecular Formula: C₁₄H₁₀N₄O₃S
• Molecular Weight: 314.32
• Purity: ≥95%
• Target: Wnt
• Solubility: DMSO: ≥100 mg/mL
• IUPAC Name: (5Z)-5-[[1-(4-nitrophenyl)pyrrol-2-yl]methylidene]-2-sulfanylideneimidazolidin-4-one
• InChI: InChI=1S/C14H10N4O3S/c19-13-12(15-14(22)16-13)8-11-2-1-7-17(11)9-3-5-10(6-4-9)18(20)21/h1-8H,(H2,15,16,19,22)/b12-8-
• InChIKey: FMLUAKSJMUPACD-WQLSENKSSA-N
• SMILES: C1=CN(C(=C1)C=C2C(=O)NC(=S)N2)C3=CC=C(C=C3)[N+](=O)[O-]

KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.

Reference

[1]. Cha PH, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600.