Kynuramine dihydrochloride

• CAT Number: I045546
• CAS Number: 36681-58-0
• Molecular Formula: C9H14Cl2N2O
• Molecular Weight: 237.13
• Purity: ≥95%
• Synonyms: 3-amino-1-(2-aminophenyl)propan-1-one;dihydrochloride
• InChI: InChI=1S/C9H12N2O.2ClH/c10-6-5-9(12)7-3-1-2-4-8(7)11;;/h1-4H,5-6,10-11H2;2*1H
• InChIKey: GIUIHRRGPBPUAO-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)CCN)N.Cl.Cl

Kynuramine, an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].
Kynuramine inhibits both presynaptic and postsynaptic α-adrenoceptors in vitro[2].
Kynuramine has been shown to act as a partial agonist on serotonin receptors in dog cerebral arteries[2].
Kynuramine (20 μg/mL) frequently causes a small contraction of the ileum but failed to alter the twitch response to cholinergic stimulation[2].
Kynuramine (0.064, 0.32, 1.6 or 8 μg; ICV; single does) may serve a physiological role in the modulation of female sexual behavior[3].
Kynuramine (1.25, 2.5 and 5.0 mg/kg; i.v.; single does) increases heart rate and blood pressure in pithed rats[4].

Reference

[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4.
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[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6.
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[3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51.
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[4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.
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