L 642946

• CAT Number: I030282
• CAS Number: 80730-81-0
• Molecular Formula: C24H20N5NaO5S4
• Molecular Weight: 609.68
• Purity: 98%
• Synonyms: L 642946; L-642946; L642946
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: sodium (6R,7R)-7-((1-benzylpyridin-1-ium-4-yl)amino)-3-(((5-((carboxylatomethyl)thio)-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• InChI: InChI=1S/C24H21N5O5S4.Na/c30-17(31)13-37-24-27-26-23(38-24)36-12-15-11-35-21-18(20(32)29(21)19(15)22(33)34)25-16-6-8-28(9-7-16)10-14-4-2-1-3-5-14;/h1-9,18,21H,10-13H2,(H2,30,31,33,34);/q;+1/p-1/t18-,21-;/m1./s1
• InChIKey: MYJKOJOAXNZQEL-IUFJOMBNSA-M
• SMILES: O=C1[C@@H](NC2=CC=[N+](CC3=CC=CC=C3)C=C2)[C@@]4([H])SCC(CSC5=NN=C(SCC([O-])=O)S5)=C(C([O-])=O)N14.[Na+]

L 642946(CAT: I030282) is a potent and selective endothelin receptor antagonist, extensively used in cardiovascular and renal research. By blocking the activity of endothelin-1 on ETA and ETB receptors, it effectively modulates vasoconstriction and inflammation pathways, making it a valuable tool for investigating conditions such as hypertension, pulmonary arterial hypertension (PAH), and chronic kidney disease (CKD). Its high affinity and specificity for endothelin receptors ensure accurate experimental results in both in vitro and in vivo studies. With exceptional purity and stability, L 642946 supports the development of therapeutic strategies targeting endothelin-mediated disorders in cardiovascular and renal research.