L-655708

• CAT Number: I001168
• CAS Number: 130477-52-0
• Molecular Formula: C18H19N3O4
• Molecular Weight: 341.37
• Purity: ≥95%
• Synonyms: (S)-ethyl 7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Desiccate at +4C
• IUPAC Name: ethyl (7S)-15-methoxy-12-oxo-2,4,11-triazatetracyclo[11.4.0.02,6.07,11]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate
• InChI: 1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
• InChIKey: YKYOQIXTECBVBB-AWEZNQCLSA-N
• SMILES: CCOC(=O)C1=C2[C@@H]3CCCN3C(=O)C4=C(N2C=N1)C=CC(=C4)OC

L-655708 (Cat No.: I001168) is a selective inverse agonist of the benzodiazepine site on GABAA receptors, with high affinity for the α5 subunit-containing receptors. By selectively modulating these receptors, L-655708 reduces inhibitory neurotransmission, particularly in the hippocampus, which is associated with cognitive processes. It has been widely used in preclinical studies to explore its potential in enhancing learning and memory. L-655708 is also investigated for its implications in neuropsychiatric and neurodegenerative disorders, making it a valuable tool in neuroscience research.

Reference

[1]. Saab BJ, et al. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptorinverse agonist L-655708. Anesthesiology. 2010 Nov;113(5):1061-1071.