For research use only. Not for therapeutic Use.
L-67（Cat No.:I003153）is a small molecule inhibitor that targets the enzyme phosphatidylinositol 3-kinase (PI3K), a critical regulator of cell survival, growth, and metabolism. By inhibiting PI3K, L-67 disrupts key signaling pathways involved in cancer cell proliferation, survival, and resistance to apoptosis. It has shown promise as a potential therapeutic agent in various cancers, including breast, prostate, and leukemia, by blocking tumor growth and metastasis. Research continues to explore its efficacy in combination with other cancer therapies, as well as its safety and pharmacokinetics for potential clinical application.
| Catalog Number | I003153 |
| CAS Number | 325970-71-6 |
| Synonyms | L67 ( Cat No. : I003153 ) is a novel competitive DNA ligase inhibitor that inhibits DNA ligase I and III with an IC50 of 10 μM. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours. |
| Molecular Formula | C₁₆H₁₄Br₂N₄O₄ |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | DMSO: ≥ 33 mg/mL |
| Storage | Store at -20°C |
| IC50 | 10 μM |
| IUPAC Name | 2-(3,5-dibromo-4-methylanilino)-N-[(E)-(2-hydroxy-5-nitrophenyl)methylideneamino]acetamide |
| InChI | InChI=1S/C16H14Br2N4O4/c1-9-13(17)5-11(6-14(9)18)19-8-16(24)21-20-7-10-4-12(22(25)26)2-3-15(10)23/h2-7,19,23H,8H2,1H3,(H,21,24)/b20-7+ |
| InChIKey | KFEPVFJQVOMODD-IFRROFPPSA-N |
| SMILES | CC1=C(C=C(C=C1Br)NCC(=O)N/N=C/C2=C(C=CC(=C2)[N+](=O)[O-])O)Br |
| Reference | </br>1:The anti-allergic activity of Lactobacillus plantarum L67 and its application to yogurt. Song S, Lee SJ, Park DJ, Oh S, Lim KT.J Dairy Sci. 2016 Dec;99(12):9372-9382. doi: 10.3168/jds.2016-11809. Epub 2016 Oct 13. PMID: 27743673 </br>2:Lactobacillus plantarum L67 glycoprotein protects against cadmium chloride toxicity in RAW 264.7 cells. Song S, Oh S, Lim KT.J Dairy Sci. 2016 Mar;99(3):1812-21. doi: 10.3168/jds.2015-10121. Epub 2016 Jan 13. PMID: 26774722 </br>3:Bioactivity of proteins isolated from Lactobacillus plantarum L67 treated with Zanthoxylum piperitum DC glycoprotein. Song S, Oh S, Lim KT.Lett Appl Microbiol. 2015 Jun;60(6):597-604. doi: 10.1111/lam.12416. Epub 2015 Apr 8. PMID: 25773674 </br>4:The proteins (12 and 15 kDa) isolated from heat-killed Lactobacillus plantarum L67 induces apoptosis in HT-29 cells. Song S, Oh S, Lim KT.Cell Biochem Funct. 2015 Mar;33(2):89-96. doi: 10.1002/cbf.3094. Epub 2015 Feb 20. PMID: 25703965 </br>5:Cold stress improves the ability of Lactobacillus plantarum L67 to survive freezing. Song S, Bae DW, Lim K, Griffiths MW, Oh S.Int J Food Microbiol. 2014 Nov 17;191:135-43. doi: 10.1016/j.ijfoodmicro.2014.09.017. Epub 2014 Sep 18. PMID: 25261832 </br>6:Mutation of single hydrophobic residue I27, L35, F39, L58, L65, L67, or L71 in the N terminus of VP5 abolishes interaction with the scaffold protein and prevents closure of herpes simplex virus type 1 capsid shells. Walters JN, Sexton GL, McCaffery JM, Desai P.J Virol. 2003 Apr;77(7):4043-59. PMID: 12634364 Free PMC Article</br>7:The role of the M6-M7 loop (L67) in stabilization of the phosphorylation and Ca(2+) binding domains of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA). Zhang Z, Lewis D, Sumbilla C, Inesi G, Toyoshima C.J Biol Chem. 2001 May 4;276(18):15232-9. Epub 2001 Feb 5. PMID: 11278755 Free Article</br>8:[Clinical use of citanest (L67, Astra)]. Suzuki H.Masui. 1965 Feb;14(2):159-65. Japanese. No abstract available. PMID: 5892535 </br>9:[Citanest (L67)–a new local anesthetic]. von BAHR, ERIKSSON E.Sven Lakartidn. 1962 Aug 2;59:2221-32. Swedish. No abstract available. PMID: 13863977 |
