For research use only. Not for therapeutic Use.
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2].
L-689560 is a 2-carboxytetrahydroquinoline antagonist[2].
L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1]
| Catalog Number | M114679 |
| CAS Number | 139051-78-8 |
| Synonyms | (2R,4S)-5,7-dichloro-4-(phenylcarbamoylamino)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid |
| Molecular Formula | C17H15Cl2N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1 |
| InChIKey | UCKHICKHGAOGAP-UONOGXRCSA-N |
| SMILES | C1C(C2=C(C=C(C=C2Cl)Cl)NC1C(=O)O)NC(=O)NC3=CC=CC=C3 |
| Reference | [1]. Juan Chen, et al. A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. 15 June 2017 [2]. Kvist T, et al. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem. 2013 Nov 15;288(46):33124-35. |
