For research use only. Not for therapeutic Use.
L690330 is a potent inhibitor of inositol monophophatase. L690330 induces autophagy in COS-7 cells independently of mTOR inhibition.
| Catalog Number | M102481 |
| CAS Number | 142523-38-4 |
| Synonyms | (1-(4-hydroxyphenoxy)ethane-1,1-diyl)diphosphonic acid |
| Molecular Formula | C8H12O8P2 |
| Purity | ≥95% |
| Target | Phosphatase |
| Solubility | Soluble to 100 mM in sterile water |
| Storage | Store at RT |
| IUPAC Name | [1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid |
| InChI | InChI=1S/C8H12O8P2/c1-8(17(10,11)12,18(13,14)15)16-7-4-2-6(9)3-5-7/h2-5,9H,1H3,(H2,10,11,12)(H2,13,14,15) |
| InChIKey | JKOCAAWWDVHWKB-UHFFFAOYSA-N |
| SMILES | CC(OC1=CC=C(C=C1)O)(P(=O)(O)O)P(=O)(O)O |
| Reference | </br>1:The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test. Shtein L, Toker L, Bersudsky Y, Belmaker RH, Agam G.Psychopharmacology (Berl). 2013 Jun;227(3):503-8. doi: 10.1007/s00213-013-2969-0. Epub 2013 Jan 24. PMID: 23344554 </br>2:Effects of L-690,488, a prodrug of the bisphosphonate inositol monophosphatase inhibitor L-690,330, on phosphatidylinositol cycle markers. Atack JR, Prior AM, Fletcher SR, Quirk K, McKernan R, Ragan CI.J Pharmacol Exp Ther. 1994 Jul;270(1):70-6. PMID: 8035344 </br>3:In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. Atack JR, Cook SM, Watt AP, Fletcher SR, Ragan CI.J Neurochem. 1993 Feb;60(2):652-8. PMID: 8380439 |
