For research use only. Not for therapeutic Use.
L-701252 is a potent antagonist of glycine site NMDA receptor with an IC50 of 420 nM. L-701252 provides a small degree of neuroprotection in global cerebral ischaemia[1].
L-701252 (50 mg/kg; i.p.) provides a small non-significant protection[1].
| Catalog Number | M093622 |
| CAS Number | 151057-13-5 |
| Synonyms | 7-chloro-3-(cyclopropanecarbonyl)-4-hydroxy-1H-quinolin-2-one |
| Molecular Formula | C13H10ClNO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H10ClNO3/c14-7-3-4-8-9(5-7)15-13(18)10(12(8)17)11(16)6-1-2-6/h3-6H,1-2H2,(H2,15,17,18) |
| InChIKey | MXEFWCFPCLDOOG-UHFFFAOYSA-N |
| SMILES | C1CC1C(=O)C2=C(C3=C(C=C(C=C3)Cl)NC2=O)O |
| Reference | [1]. Stone TW. Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. Trends Pharmacol Sci. 2000;21(4):149-154. [2]. Widdowson PS, et al. Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors. Brain Res. 1996;738(2):236-242. |
