L-739758

• CAT Number: I030376
• CAS Number: 168157-33-3
• Molecular Formula: C22H26N4O5S3
• Molecular Weight: 522.65
• Purity: 98%
• Synonyms: L-739758; L 739758; L739758
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (2S)-3-[[2-(2-piperidin-4-ylethyl)thieno[2,3-b]thiophene-5-carbonyl]amino]-2-(pyridin-3-ylsulfonylamino)propanoic acid
• InChI: InChI=1S/C22H26N4O5S3/c27-20(25-13-18(21(28)29)26-34(30,31)17-2-1-7-24-12-17)19-11-15-10-16(32-22(15)33-19)4-3-14-5-8-23-9-6-14/h1-2,7,10-12,14,18,23,26H,3-6,8-9,13H2,(H,25,27)(H,28,29)/t18-/m0/s1
• InChIKey: QDIFCBMBPLLNGR-SFHVURJKSA-N
• SMILES: O=C(O)[C@@H](NS(=O)(C1=CC=CN=C1)=O)CNC(C(S2)=CC3=C2SC(CCC4CCNCC4)=C3)=O

L-739758 is a glycoprotein IIb/IIIa inhibitor.

Reference

1: Shen YT, Wiedmann RT, Lynch JJ Jr, Gould RJ. Platelet glycoprotein IIb/IIIa receptor inhibitor preserves coronary flow reserve during progressive coronary arteriostenosis in swine. Arterioscler Thromb Vasc Biol. 2000 Oct;20(10):2309-15. PubMed PMID: 11031220.
2: Bednar B, Cook JJ, Holahan MA, Cunningham ME, Jumes PA, Bednar RA, Hartman GD, Gould RJ. Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa. Blood. 1999 Jul 15;94(2):587-99. PubMed PMID: 10397726.