For research use only. Not for therapeutic Use.
L-742001 hydrochloride is an inhibitor of influenza virus PA endonuclease. Moreover, L-742001 is a first-in-class highly selective inhibitor of cap-dependent endonuclease of influenza viruses (IC50 value of 0.43 µM for in vitro influenza virus transcription). KEYWORDS: L-742001 hydrochloride | Supplier | PA endonuclease inhibitor | L742001 | L 742001 | CAS [177592-42-6] | CAS [174605-64-2] | DNA-RNA | Endonuclease | Inhibitor | Enzymes | Influenza virus | Influenza virus PA endonuclease | Influenza A virus polymerase acidic protein
| Catalog Number | I012523 |
| CAS Number | 174605-64-2 |
| Molecular Formula | C23H24ClNO4.HCl |
| Purity | ≥95% |
| IUPAC Name | (Z)-4-[1-benzyl-4-[(4-chlorophenyl)methyl]piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid;hydrochloride |
| InChI | InChI=1S/C23H24ClNO4.ClH/c24-19-8-6-17(7-9-19)15-23(21(27)14-20(26)22(28)29)10-12-25(13-11-23)16-18-4-2-1-3-5-18;/h1-9,14,26H,10-13,15-16H2,(H,28,29);1H/b20-14-; |
| SMILES | C1CN(CCC1(CC2=CC=C(C=C2)Cl)C(=O)/C=C(/C(=O)O)\O)CC3=CC=CC=C3.Cl |
| Reference | JC Hastings et al. Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors. Antimicrob Agents Chemother. 1996 May;40(5):1304-7.A Stevaert et al. An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease. Mol Pharmacol. 2015 Feb;87(2):323-37. |
