For research use only. Not for therapeutic Use.
L-775,606 is a selective 5-hydroxytryptamine 1D agonist.
| Catalog Number | I007594 |
| CAS Number | 188400-51-3 |
| Synonyms | L-775,606; L 775,606; L775,606.;3-[3-[4-[2-(3-fluorophenyl)ethyl]piperazin-1-yl]propyl]-5-(1,2,4-triazol-4-yl)-1H-indole |
| Molecular Formula | C25H29FN6 |
| Purity | ≥95% |
| Target | 5-hydroxytryptamine 1D Agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 3-[3-[4-[2-(3-fluorophenyl)ethyl]piperazin-1-yl]propyl]-5-(1,2,4-triazol-4-yl)-1H-indole |
| InChI | InChI=1S/C25H29FN6/c26-22-5-1-3-20(15-22)8-10-31-13-11-30(12-14-31)9-2-4-21-17-27-25-7-6-23(16-24(21)25)32-18-28-29-19-32/h1,3,5-7,15-19,27H,2,4,8-14H2 |
| InChIKey | ZUTQCPBDRJBADG-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCCC2=CNC3=C2C=C(C=C3)N4C=NN=C4)CCC5=CC(=CC=C5)F |
| Reference | </br>1:Quantitative determination of L-775,606, a selective 5-hydroxytryptamine 1D agonist, in rat plasma using automated sample preparation and detection by liquid chromatography-tandem mass spectrometry. Locker KL, Morrison D, Watt AP.J Chromatogr B Biomed Sci Appl. 2001 Jan 5;750(1):13-23. PMID: 11204213 </br>2:Comparison of the vasoconstrictor effects of the selective 5-HT1D-receptor agonist L-775,606 with the mixed 5-HT1B/1D-receptor agonist sumatriptan and 5-HT in human isolated coronary artery. Longmore J, Maguire JJ, MacLeod A, Street L, Schofield WN, Hill RG.Br J Clin Pharmacol. 2000 Feb;49(2):126-31. PMID: 10671906 Free PMC Article</br>3:Interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase in hepatic metabolism of L-775,606, a potent 5-HT(1D) receptor agonist. Prueksaritanont T, Lu P, Gorham L, Sternfeld F, Vyas KP.Xenobiotica. 2000 Jan;30(1):47-59. PMID: 10659950 |
