For research use only. Not for therapeutic Use.
L-778123 free base（Cat No.:I030393）is a selective small-molecule inhibitor of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. This enzyme plays a key role in the conversion of inactive cortisone to active cortisol in peripheral tissues, influencing the regulation of glucose, fat, and protein metabolism. By inhibiting 11β-HSD1, L-778123 has potential therapeutic applications in treating conditions related to cortisol excess, such as obesity, type 2 diabetes, and metabolic syndrome. Preclinical studies have demonstrated its ability to reduce cortisol levels and improve metabolic outcomes, although further clinical trials are needed to assess its safety and efficacy.
| Catalog Number | I030393 |
| CAS Number | 183499-57-2 |
| Synonyms | L-778123 free base; L-778123; L 778123; L778123; L-778,123; L 778,123; L778,123; |
| Molecular Formula | C22H20ClN5O |
| Purity | 98% |
| Target | Farnesyl Transferase |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile |
| InChI | InChI=1S/C22H20ClN5O/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18/h1-7,10,12,16H,8-9,13-15H2 |
| InChIKey | JNUGFGAVPBYSHF-UHFFFAOYSA-N |
| SMILES | C1CN(C(=O)CN1CC2=CN=CN2CC3=CC=C(C=C3)C#N)C4=CC(=CC=C4)Cl |
| Reference | 1: Ghasemi S, Davaran S, Sharifi S, Asgari D, Abdollahi A, Shahbazi Mojarrad J. Comparison of Cytotoxic Activity of L778123 as a Farnesyltranferase Inhibitor and Doxorubicin against A549 and HT-29 Cell Lines. Adv Pharm Bull. 2013;3(1):73-7. doi: 10.5681/apb.2013.012. Epub 2013 Feb 7. PubMed PMID: 24312815; PubMed Central PMCID: PMC3846042. |
