L-779450

• CAT Number: I003063
• CAS Number: 303727-31-3
• Molecular Formula: C₂₀H₁₄ClN₃O
• Molecular Weight: 347.80
• Purity: ≥95%
• Synonyms: 2-chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol
• Target: Raf
• Solubility: 100 mM in DMSO
• Storage: 2-8°C
• IUPAC Name: 2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol
• InChI: InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
• InChIKey: WXJLXRNWMLWVFB-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC(=C(C=C4)Cl)O

L-779450（Cat No.:I003063）is a potent and selective inhibitor of farnesyltransferase, an enzyme involved in the post-translational modification of proteins such as Ras, which plays a critical role in cell signaling pathways related to cancer. By inhibiting farnesyltransferase, L-779450 prevents the proper localization and function of Ras proteins, thereby disrupting cancer cell growth and survival. It has been studied in preclinical models for its potential in targeting Ras-driven tumors, including pancreatic and lung cancers. L-779450 is a valuable tool in cancer research, particularly for exploring therapeutic interventions against Ras-dependent malignancies.

Reference

[1]. Shelton JG, et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia. 2003 Sep;17(9):1765-82.
[2]. Takle AK, et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6.
[3]. McKay MM, et al. RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling. Curr Biol. 2011 Apr 12;21(7):563-8.