For research use only. Not for therapeutic Use.
L-826266 is a selective and competitive EP3 receptor antagonist. L-826266 can be used for convulsive disorders research[1].
In adult rat hippocampal slices, L-826266 (1 μM) prevents the PGE2-induced decrease of Na+,K+-ATPase activity[2].
L-826266 (0.01-1 nmol/site; i.c.v.; once) delays seizures, and increases the latency for clonic and generalized tonic-clonic seizures induced by PTZ[1].
| Catalog Number | I007603 |
| CAS Number | 244101-03-9 |
| Synonyms | (E)-N-(5-bromo-2-methoxyphenyl)sulfonyl-3-[5-chloro-2-(naphthalen-2-ylmethyl)phenyl]prop-2-enamide |
| Molecular Formula | C27H21BrClNO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C27H21BrClNO4S/c1-34-25-12-10-23(28)17-26(25)35(32,33)30-27(31)13-9-22-16-24(29)11-8-21(22)15-18-6-7-19-4-2-3-5-20(19)14-18/h2-14,16-17H,15H2,1H3,(H,30,31)/b13-9+ |
| InChIKey | DYXFUJYHEDGCLS-UKTHLTGXSA-N |
| SMILES | COC1=C(C=C(C=C1)Br)S(=O)(=O)NC(=O)C=CC2=C(C=CC(=C2)Cl)CC3=CC4=CC=CC=C4C=C3 |
| Reference | [1]. M S Oliveira, et al. Modulation of pentylenetetrazol-induced seizures by prostaglandin E2 receptors. Neuroscience. 2008 Apr 9;152(4):1110-8. [2]. Mauro Schneider Oliveira, et al. Prostaglandin E2 modulates Na+,K+-ATPase activity in rat hippocampus: implications for neurological diseases. J Neurochem. 2009 Apr;109(2):416-26. |
