L-Asparagine-13C4,15N2,d3 monohydrate

• CAT Number: I044746
• CAS Number: 2483829-30-5
• Molecular Formula: 13C4H7D3 15N2O4
• Molecular Weight: 159.11
• Purity: ≥95%
• Synonyms: (2S)-2,4-bis(15N)(azanyl)-2,3,3-trideuterio-4-oxo(1,2,3,4-13C4)butanoic acid;hydrate
• InChI: InChI=1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1/i1+1D2,2+1D,3+1,4+1,5+1,6+1
• InChIKey: RBMGJIZCEWRQES-DIWHROOWSA-N
• SMILES: C(C(C(=O)O)N)C(=O)N.O

L-Asparagine-13C4,15N2,d3 (monohydrate) is the deuterium, 13C-, and 15-labeled L-Asparagine monohydrate. L-Asparagine monohydrate ((-)-Asparagine monohydrate) is a non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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