l-Atabrine dihydrochloride

• CAT Number: I020333
• CAS Number: 56100-42-6
• Molecular Formula: C₂₃H₃₂Cl₃N₃O
• Molecular Weight: 472.88
• Purity: ≥95%
• Target: Bacterial
• Storage: Store at -20°C
• IUPAC Name: (4R)-4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrochloride
• InChI: InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H/t16-;;/m1../s1
• InChIKey: UDKVBVICMUEIKS-GGMCWBHBSA-N
• SMILES: CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl

l-Atabrine dihydrochloride (Cat No.:I020333) is a synthetic antimalarial agent historically used to prevent and treat malaria. As a derivative of acridine, it works by interfering with the parasite’s DNA, inhibiting its replication within red blood cells. Besides its antimalarial action, l-Atabrine dihydrochloride has demonstrated anti-inflammatory and antiparasitic properties, which has led to investigations into its potential use in autoimmune diseases and other parasitic infections. Though largely replaced by newer drugs, it remains a compound of interest in research for its broad biological activity and unique chemical structure.

Reference

[1]. Ryou C, et al. Differential inhibition of prion propagation by enantiomers of quinacrine. Lab Invest. 2003 Jun;83(6):837-43.