L-Buthionine-(S,R)-sulfoximine

• CAT Number: R000634
• CAS Number: 83730-53-4
• Molecular Formula: C8H18N2O3S
• Molecular Weight: 222.30
• Purity: ≥95%
• Synonyms: (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic Acid; L-Buthionine Sulfoximine; NSC 326231
• Storage: -20°C
• IUPAC Name: (2S)-2-amino-4-(butylsulfonimidoyl)butanoic acid
• InChI: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
• InChIKey: KJQFBVYMGADDTQ-CVSPRKDYSA-N
• SMILES: CCCCS(=N)(=O)CCC(C(=O)O)N

L-Buthionine-(S,R)-sulfoximine (BSO) (Cat No.: R000634) is a synthetic compound that inhibits the enzyme gamma-glutamylcysteine synthetase (GCL), which plays a key role in the synthesis of glutathione, a major antioxidant in cells. By reducing glutathione levels, BSO can induce oxidative stress and has been used in research to study the effects of lowered glutathione in various cellular processes. It has potential applications in cancer therapy, neurodegenerative disease research, and studies involving oxidative stress mechanisms.