For research use only. Not for therapeutic Use.
L-Chicoric Acid（Cat No.:I004654）is a naturally occurring polyphenolic compound found in plants like Echinacea and Chicory. It is known for its antioxidant, anti-inflammatory, and antiviral properties. L-Chicoric Acid inhibits HIV-1 integrase, making it a subject of interest in antiviral research. Additionally, it has been studied for its potential to modulate immune responses, reduce oxidative stress, and improve skin health. Its ability to inhibit enzymes involved in viral replication and inflammation makes it valuable in exploring therapeutic applications for immune support, antiviral treatments, and anti-inflammatory therapies.
| Catalog Number | I004654 |
| CAS Number | 70831-56-0 |
| Molecular Formula | C22H18O12 |
| Purity | ≥95% |
| Solubility | 10 mM in DMSO |
| Storage | Desiccate at -20C |
| IUPAC Name | (2R,3R)-2,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]butanedioic acid |
| InChI | InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+/t19-,20-/m1/s1 |
| InChIKey | YDDGKXBLOXEEMN-IABMMNSOSA-N |
| SMILES | C1=CC(=C(C=C1/C=C/C(=O)O[C@@H](C(=O)O)[C@@H](OC(=O)/C=C/C2=CC(=C(C=C2)O)O)C(=O)O)O)O |
| Reference | <p style=/line-height:25px/> <br>[2]. W Edward Robinson Jr., et al. l-Chicoric acid, an inhibitor of human immunodeficiency virus type 1 (HIV-1) integrase, improves on the in vitro anti-HIV-1 effect of Zidovudine plus a protease inhibitor (AG1350). Antiviral Research <br>[3]. King PJ, et al. Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase. Journal of Virology, 1998, 72(10): 8420-8424 </p> |
