L-(+)-Cystathionine

• CAT Number: R000065
• CAS Number: 56-88-2
• Molecular Formula: C7H14N2O4S
• Molecular Weight: 222.259
• Purity: ≥95%
• Synonyms: S-[(2R)-2-Amino-2-carboxyethyl]-L-homocysteine; [R-(R*,S*)]-2-Amino-4-[(2-amino-2-carboxyethyl)thio]butanoic Acid
• Storage: -20°C
• IUPAC Name: (2S)-2-amino-4-[(2R)-2-amino-2-carboxyethyl]sulfanylbutanoic acid
• InChI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
• InChIKey: ILRYLPWNYFXEMH-WHFBIAKZSA-N
• SMILES: C(CSCC(C(=O)O)N)C(C(=O)O)N

L-<wbr />(+)-<wbr />Cystathionine (CAS 56-88-2) is a dipeptide formed by serine and homocysteine. Transsulfuration of methionine yields homocysteine, which combines with serine to form this precursor of cysteine. L-<wbr />(+)-<wbr />Cystathionine is largely expressed in the mammalian brain and deficiency can indicate the presence of metabolic disorders such as cystathioninuria.

Reference

1.Tallan, Harris H., Stanford Moore, and William H. Stein. "L-cystathionine in human brain." J Biol Chem 230.2 (1958): 707-716.
2.Ricci, Giorgio, et al. "Similarity of the oxidation products of L-cystathionine by L-amino acid oxidase to those excreted by cystathioninuric patients." Journal of Biological Chemistry 258.17 (1983): 10511-10517.