L-DABA hydrobromide

• CAT Number: I040803
• CAS Number: 73143-97-2
• Molecular Formula: C4H11BrN2O2
• Molecular Weight: 199.05
• Purity: ≥95%
• Synonyms: (2S)-2,4-diaminobutanoic acid;hydrobromide
• InChI: InChI=1S/C4H10N2O2.BrH/c5-2-1-3(6)4(7)8;/h3H,1-2,5-6H2,(H,7,8);1H/t3-;/m0./s1
• InChIKey: RVCHWEZQMFNGBK-DFWYDOINSA-N
• SMILES: C(CN)C(C(=O)O)N.Br

L-DABA hydrobromide(CAT: I040803), or L-2,4-Diaminobutyric acid hydrobromide, is a weak inhibitor of gamma-aminobutyric acid (GABA) transaminase, with an IC₅₀ exceeding 500 μM. It has demonstrated antitumor activity both in vitro and in vivo. For instance, incubation with 10 mM L-DABA hydrobromide for 24 hours at 37°C irreversibly damages tumor cells, likely due to osmotic lysis from intracellular accumulation. This cytotoxic effect can be mitigated by co-incubation with L-alanine and L-methionine. Kinetic studies indicate that L-DABA hydrobromide acts as a nonlinear, non-competitive inhibitor of GABA transaminase, with its induced elevation of GABA levels paralleling the enzyme’s inhibition.