L-[+]-Histidine is an essential amino acid with a basic side chain, commonly found in proteins and vital for various biological functions. It plays a crucial role in protein synthesis, enzyme catalysis, and neurotransmission. Histidine serves as a precursor for histamine, a neurotransmitter involved in allergic responses and gastric acid secretion. Additionally, histidine residues in proteins can act as ligands for metal ions, contributing to their structural stability and enzymatic activity. Due to its diverse roles, histidine is essential for overall health and is obtained through dietary sources.