L-Homocitrulline-d3

• CAT Number: I044745
• Molecular Formula: C7H12D3N3O3
• Molecular Weight: 192.23
• Purity: ≥95%
• Synonyms: (2S)-2-amino-6-(carbamoylamino)-2,6,6-trideuteriohexanoic acid
• InChI: InChI=1S/C7H15N3O3/c8-5(6(11)12)3-1-2-4-10-7(9)13/h5H,1-4,8H2,(H,11,12)(H3,9,10,13)/t5-/m0/s1/i4D2,5D
• InChIKey: XIGSAGMEBXLVJJ-UXJCOIHKSA-N
• SMILES: C(CCNC(=O)N)CC(C(=O)O)N

L-Homocitrulline-d3 is the deuterium labeled L-Homocitrulline. L-Homocitrulline is metabolized to homoarginine through homoargininosuccinate via the urea cycle pathway and its metabolic abnormality could lead to Lysinuric Protein Intolerance (LPI).
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Kato T, et al. Homocitrullinuria and homoargininuria in lysinuric protein intolerance. J Inherit Metab Dis. 1989;12(2):157-61.
 [Content Brief]