L-Homopropargyl Glycine

• CAT Number: I011776
• CAS Number: 98891-36-2
• Molecular Formula: C6H9NO2
• Molecular Weight: 127.143
• Purity: ≥95%
• Synonyms: (2S)-2-amino-5-hexynoic acid
• Target: PROTAC Linkers
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (2S)-2-aminohex-5-ynoic acid
• InChI: InChI=1S/C6H9NO2/c1-2-3-4-5(7)6(8)9/h1,5H,3-4,7H2,(H,8,9)/t5-/m0/s1
• InChIKey: SCGJGNWMYSYORS-YFKPBYRVSA-N
• SMILES: C#CCCC(C(=O)O)N

L-Homopropargyl Glycine(CAT: I011776), also known as L-HPG, is a non-proteinogenic amino acid and a synthetic compound. It is an analog of the amino acid glycine, with an additional propargyl group attached to the nitrogen atom of the amino group. L-HPG has been studied for its potential use as a chemical tool in biological research, particularly in the study of protein synthesis and post-translational modifications. It can be incorporated into proteins via the cellular machinery that normally processes glycine, allowing for the selective labeling and detection of proteins that contain L-HPG. Additionally, L-HPG has been shown to have neuroprotective properties and may have therapeutic potential in the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.