L-Homopropargylglycine hydrochloride

• CAT Number: I045294
• CAS Number: 942518-19-6
• Molecular Formula: C6H10ClNO2
• Molecular Weight: 163.60
• Purity: ≥95%
• Synonyms: (2S)-2-aminohex-5-ynoic acid;hydrochloride
• InChI: InChI=1S/C6H9NO2.ClH/c1-2-3-4-5(7)6(8)9;/h1,5H,3-4,7H2,(H,8,9);1H/t5-;/m0./s1
• InChIKey: XGBWOGGSQVMSRX-JEDNCBNOSA-N
• SMILES: C#CCCC(C(=O)O)N.Cl

L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor[1][2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018;36:553-562.
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[2]. Shen Y, et al. Protocol for visualizing newly synthesized proteins in primary mouse hepatocytes. STAR Protoc. 2021;2(3):100616. Published 2021 Jun 17.
 [Content Brief]