L-Kynurenine

• CAT Number: R063147
• CAS Number: 2922-83-0
• Molecular Formula: C10H12N2O3
• Molecular Weight: 208.217
• Purity: ≥95%
• Synonyms: Kynurenine; (αS)-α,2-Diamino-γ-oxo-benzenebutanoic Acid;?L-3-Anthraniloyl-alanine; (S)-α,2-Diamino-γ-oxo-benzenebutanoic Acid; 3-Anthraniloylalanine; Kynurenin; Kynurenine; L-3-(o-Aminobenzoyl)alanine
• Target: Metabolic Enzyme/Protease
• Solubility: >10.85mg/mL in DMSO
• Storage: Store at RT
• IUPAC Name: (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid
• InChI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1
• InChIKey: YGPSJZOEDVAXAB-QMMMGPOBSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N

L-Kynurenine (CAT: R063147) is a pivotal metabolite in the tryptophan degradation pathway, known as the kynurenine pathway, where it is derived from tryptophan through enzymatic processes. This compound serves as a crucial precursor for the synthesis of various biologically active molecules, including neuroactive and immunomodulatory substances.

Reference

1: Moroni F, Carpenedo R, Chiarugi A. Kynurenine hydroxylase and kynureninase
inhibitors as tools to study the role of kynurenine metabolites in the central
nervous system. Adv Exp Med Biol. 1996;398:203-10. Review. PubMed PMID: 8906267.

2: Stone TW, MacGregor DG, Smith RA, Jones P, Behan WM, Graham DI. Basic
mechanisms of kynurenine actions in the central nervous system. Adv Exp Med Biol.
1996;398:195-201. Review. PubMed PMID: 8906266.

3: Freese A, Swartz KJ, During MJ, Martin JB. Kynurenine metabolites of
tryptophan: implications for neurologic diseases. Neurology. 1990
Apr;40(4):691-5. Review. PubMed PMID: 2181342.

4: Gál EM, Sherman AD. L-kynurenine: its synthesis and possible regulatory
function in brain. Neurochem Res. 1980 Mar;5(3):223-39. Review. PubMed PMID:
6154900.

5: Tryptophan pyrrolase, kynurenine, and pyridoxine. Nutr Rev. 1967
Jun;25(6):170-2. Review. PubMed PMID: 4863438.