L-Methionine-d4

• CAT Number: I043810
• CAS Number: 67866-75-5
• Molecular Formula: C5H7D4NO2S
• Molecular Weight: 153.24
• Purity: ≥95%
• Synonyms: (2S)-2-amino-3,3,4,4-tetradeuterio-4-methylsulfanylbutanoic acid
• InChI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i2D2,3D2
• InChIKey: FFEARJCKVFRZRR-UGKISTHKSA-N
• SMILES: CSCCC(C(=O)O)N

L-Methionine-d4 is the deuterium labeled L-Methionine. L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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