L-Methionine [R,S]-Sulfoximine

• CAT Number: R000195
• CAS Number: 15985-39-4
• Molecular Formula: C5H12N2O3S
• Molecular Weight: 180.222
• Purity: ≥95%
• Synonyms: L-S-[3-Amino-3-carboxypropyl]-S-methyl-[R,S]-sulfoximine; (2S)-2-Amino-4-(S-methylsulfonimidoyl)butanoic Acid
• Storage: -20°C
• IUPAC Name: (2S)-2-amino-4-(methylsulfonimidoyl)butanoic acid
• InChI: InChI=1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1
• InChIKey: SXTAYKAGBXMACB-DPVSGNNYSA-N
• SMILES: CS(=N)(=O)CCC(C(=O)O)N

L-Methionine sulfoximine (MSO) is an inhibitor of the enzyme, glutamine synthetase (GS). L-Methionine sulfoximine,  is manufactured in Ghent, Belgium, and has been fully characterized by FTIR, HNMR, HPLC, and mass spectrometry. L-Methionine sulfoximine, is suitable for use as an ancillary material in upstream biomanufacturing applications and processes.L-Methionine sulfoximine is a specific and irreversible inhibitor of glutamine synthetase which catalyzes the formation of glutamine from the condensation of glutamate and ammonia.

Reference

Wurm, Florian M. /Production of Recombinant Protein Therapeutics in Cultivated Mammalian Cells./ Nature.com. Macmillan Publishers, 4 Nov. 2004. Web. 23 Dec. 2016.