L-Phenylalanine

• CAT Number: I004417
• CAS Number: 63-91-2
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.19
• Purity: ≥95%
• Target: Calcium Channel
• Solubility: H2O: ≥ 46 mg/mL
• Storage: 3 years -20C powder
• IC50: 980 nM [1]

L-Phenylalanine (Cat.No:I004417) is an essential amino acid commonly found in dietary protein sources. It plays a crucial role in protein synthesis and serves as a precursor for several important compounds in the body, including neurotransmitters like dopamine and norepinephrine. L-Phenylalanine is also used in the production of food additives and pharmaceuticals.

Reference

[1]. Mortell, K.H., et al., Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett, 2006. 16(5): p. 1138-41.
[2]. Glushakov, A.V., et al., Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria. Mol Psychiatry, 2002. 7(4): p. 359-67.
[3]. Glushakov, A.V., et al., L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses. J Neurosci Res, 2003. 72(1): p. 116-24.
[4]. Glushakov, A.V., et al., Long-term changes in glutamatergic synaptic transmission in phenylketonuria. Brain, 2005. 128(Pt 2): p. 300-7.
[5]. Moller, H.E., et al., Brain imaging and proton magnetic resonance spectroscopy in patients with phenylketonuria. Pediatrics, 2003. 112(6 Pt 2): p. 1580-3.