l-Pindolol

• CAT Number: I006599
• CAS Number: 26328-11-0
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.32
• Purity: ≥95%
• Synonyms: (2S)-1-(1H-indol-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
• InChI: InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3/t11-/m0/s1
• InChIKey: JZQKKSLKJUAGIC-NSHDSACASA-N
• SMILES: CC(C)NCC(COC1=CC=CC2=C1C=CN2)O

l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease[1][2][3].
l-Pindolol (500 nM and 1 μM) antagonizes the hyperpolarizing effect of both 5-carboxamidotryptamine (5-CT; 10 nM) and 5-Hydroxytryptamine (5-HT; 15 μM) by testing the membrane hyperpolarization induced by 5-CT or 5-HT on CA1 pyramidal cells[1].
l-Pindolol (1 nM-100 μM) inhibits the hyperpolarization in the hippocampus of CA1 pyramidal cells that induced by 100 nM 5-CT with an IC50 value of 92 nM[1].
l-Pindolol (1 nM-100 μM) inhibits the hyperpolarization of CA3 neurones induced by 300 nM 5-CT with an IC50 value of 522 nM[1].
l-Pindolol (15 mg/kg; i.p., pretreatment before [3H]-WAY 100635 injection) reduces [3H]-WAY 100635 accumulation of 5-HT1A receptor-containing brain areas[1].