L-Pyroglutamic acid-d5

• CAT Number: R040450
• CAS Number: 1086136-22-2
• Molecular Formula: C5H2D5NO3
• Molecular Weight: 134.14
• Purity: ≥95%
• Synonyms: (2S)-2,3,3,4,4-pentadeuterio-5-oxopyrrolidine-2-carboxylic acid
• InChI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1/i1D2,2D2,3D
• InChIKey: ODHCTXKNWHHXJC-NKXUJHECSA-N
• SMILES: C1CC(=O)NC1C(=O)O

L-Pyroglutamic acid-d5 is the deuterium labeled L-Pyroglutamic acid. L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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