For research use only. Not for therapeutic Use.
L-Saccharopine (Cat.No:I014453) is an intermediate compound involved in the metabolism of the amino acids lysine and alpha-ketoglutarate. It is formed by the condensation of these two amino acids and is further processed in the metabolic pathway. L-Saccharopine plays a role in the degradation and conversion of lysine, contributing to overall amino acid metabolism in the body.
| Catalog Number | I014453 |
| CAS Number | 997-68-2 |
| Synonyms | L-Saccharopine; accharopin; Saccharopine;;((S)-5-amino-5-carboxypentyl)-L-glutamic acid |
| Molecular Formula | C11H20N2O6 |
| Purity | ≥95% |
| Target | Endogenous Metabolite |
| Solubility | Soluble in DMSO |
| InChI | InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/t7-,8-/m0/s1 |
| InChIKey | ZDGJAHTZVHVLOT-YUMQZZPRSA-N |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NCCCC[C@H](N)C(O)=O |
| Reference | </br>1: Sato T, Ito Y, Nagasawa T. Regulatory effects of the L-lysine metabolites, L-2-aminoadipic acid and L-pipecolic acid, on protein turnover in C2C12 myotubes. Biosci Biotechnol Biochem. 2016 Jul 18:1-8. [Epub ahead of print] PubMed PMID: 27427787.</br>2: Pena IA, Marques LA, Laranjeira AB, Yunes JA, Eberlin MN, Arruda P. Simultaneous detection of lysine metabolites by a single LC-MS/MS method: monitoring lysine degradation in mouse plasma. Springerplus. 2016 Feb 25;5:172. doi: 10.1186/s40064-016-1809-1. eCollection 2016. PubMed PMID: 27026869; PubMed Central PMCID: PMC4766172.</br>3: Kumar VP, Thomas LM, Bobyk KD, Andi B, Cook PF, West AH. Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2012 Jan 31;51(4):857-66. doi: 10.1021/bi201808. Epub 2012 Jan 23. PubMed PMID: 22243403; PubMed Central PMCID: PMC3297426.</br>4: Yoshida N, Akazawa S, Katsuragi T, Tani Y. Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe. J Biosci Bioeng. 2004;97(4):278-80. PubMed PMID: 16233628.</br>5: Storts DR, Bhattacharjee JK. Purification and properties of saccharopine dehydrogenase (glutamate forming) in the Saccharomyces cerevisiae lysine biosynthetic pathway. J Bacteriol. 1987 Jan;169(1):416-8. PubMed PMID: 3098733; PubMed Central PMCID: PMC211784.</br>6: Hermann P, Meinel K. [A simple method for extraction of L-saccharopine from Neurospora crassa]. Pharmazie. 1976;31(2):132. German. PubMed PMID: 134378. </br> </br> |
