For research use only. Not for therapeutic Use.
L-Selenocystine is a diselenide-bridged amino acid that may be confused with selenocysteine (Sec), which is a rare amino acid featuring a single selenium atom. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions. This compound can be reduced by low molecular thiols and disulfide reductases to Sec. It is reduced to Sec by mammalian thioredoxin reductase (apparent K<sub>m</sub> = 6.0 µM), and this property can be used to assay thioredoxin reductase activity. L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types.
| Catalog Number | R065636 |
| CAS Number | 29621-88-3 |
| Synonyms | Seleno-L-cystine |
| Molecular Formula | C6H12N2O4Se2 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (2R)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]diselanyl]propanoic acid |
| InChI | InChI=1S/C6H12N2O4Se2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1 |
| InChIKey | JULROCUWKLNBSN-IMJSIDKUSA-N |
| SMILES | C(C(C(=O)O)N)[Se][Se]CC(C(=O)O)N |
| Reference | 1.Spallholz, J.E. On the nature of selenium toxicity and carcinostatic activity. Free Radical Biology & Medicine 17(1), 45-64 (1994). |
