L-Stepholidine

• CAT Number: I002166
• CAS Number: 16562-13-3
• Molecular Formula: C19H21NO4
• Molecular Weight: 327.37
• Purity: ≥95%
• Synonyms: 3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline-2,10-diol
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (13aS)-3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol
• InChI: InChI=1S/C19H21NO4/c1-23-18-8-12-5-6-20-10-14-11(3-4-16(21)19(14)24-2)7-15(20)13(12)9-17(18)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
• InChIKey: JKPISQIIWUONPB-HNNXBMFYSA-N
• SMILES: OC1=C(OC)C=C(CCN2CC3=C(OC)C(O)=CC=C3C[C@]24[H])C4=C1

L-Stepholidine (Cat.No:I002166) is a natural alkaloid derived from the plant Stephania intermedia. It exhibits unique pharmacological properties and has been studied for its potential therapeutic applications, particularly in the treatment of neurological disorders. L-Stepholidine has shown neuroprotective, anti-inflammatory, and antipsychotic effects, making it a subject of interest in neuroscience research.

Reference

1:L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer/’s disease via activating dopamine D1 receptor/PKA signaling pathway. Hao JR, Sun N, Lei L, Li XY, Yao B, Sun K, Hu R, Zhang X, Shi XD, Gao C.Cell Death Dis. 2015 Nov 5;6:e1965. doi: 10.1038/cddis.2015.315. PMID: 26539912 Free PMC Article2:L-stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement. Ma B, Yue K, Chen L, Tian X, Ru Q, Gan Y, Wang D, Jin G, Li C.Neurosci Lett. 2014 Jan 24;559:67-71. doi: 10.1016/j.neulet.2013.10.066. Epub 2013 Nov 20. PMID: 24269875 3:L-Stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates heroin self-administration and cue-induced reinstatement in rats. Yue K, Ma B, Chen L, Tian X, Ru Q, Gan Y, Wang D, Jin G, Li C.Neuroreport. 2014 Jan 8;25(1):7-11. doi: 10.1097/WNR.0000000000000012. PMID: 24145772 4:l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Gao M, Chu HY, Jin GZ, Zhang ZJ, Wu J, Zhen XC.Synapse. 2011 May;65(5):379-87. doi: 10.1002/syn.20855. Epub 2010 Sep 24. PMID: 20803620 5:Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand. Guo Y, Zhang H, Chen X, Cai W, Cheng J, Yang Y, Jin G, Zhen X.Schizophr Res. 2009 Nov;115(1):41-9. doi: 10.1016/j.schres.2009.08.002. Epub 2009 Sep 9. PMID: 19744833 6:D(1)/D(2) receptor-targeting L-stepholidine, an active ingredient of the Chinese herb Stephonia, induces non-rapid eye movement sleep in mice. Qiu MH, Qu WM, Xu XH, Yan MM, Urade Y, Huang ZL.Pharmacol Biochem Behav. 2009 Nov;94(1):16-23. doi: 10.1016/j.pbb.2009.06.018. Epub 2009 Jul 12. PMID: 19604496 7:L-stepholidine reduced L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson/’s disease. Mo J, Zhang H, Yu LP, Sun PH, Jin GZ, Zhen X.Neurobiol Aging. 2010 Jun;31(6):926-36. doi: 10.1016/j.neurobiolaging.2008.06.017. Epub 2008 Aug 15. PMID: 18707801 8:The antipsychotic potential of l-stepholidine–a naturally occurring dopamine receptor D1 agonist and D2 antagonist. Natesan S, Reckless GE, Barlow KB, Odontiadis J, Nobrega JN, Baker GB, George SR, Mamo D, Kapur S.Psychopharmacology (Berl). 2008 Aug;199(2):275-89. doi: 10.1007/s00213-008-1172-1. Epub 2008 Jun 3. PMID: 18521575 9:Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications. Mo J, Guo Y, Yang YS, Shen JS, Jin GZ, Zhen X.Curr Med Chem. 2007;14(28):2996-3002. Review. PMID: 18220736 10:l-Stepholidine increases the frequency of sEPSC via the activation of D1 dopamine signaling pathway in rat prelimbic cortical neurons. Gao M, Liu CL, Yang S, Zhen XC, Jin GZ.Acta Pharmacol Sin. 2007 May;28(5):627-33. PMID: 17439718 Free Article