L-Threonine-13C4

• CAT Number: I041641
• CAS Number: 55443-53-3
• Molecular Formula: 13C4H9NO3
• Molecular Weight: 123.09
• Purity: ≥95%
• Synonyms: (2S,3R)-2-amino-3-hydroxy(1,2,3,4-13C4)butanoic acid
• InChI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1/i1+1,2+1,3+1,4+1
• InChIKey: AYFVYJQAPQTCCC-GGLUNYCGSA-N
• SMILES: CC(C(C(=O)O)N)O

L-Threonine-13C4 is the 13C labeled L-Threonine[1]. L-Threonine is a natural amino acid, can be produced by microbial fermentation, and is used in food, medicine, or feed[2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Reference

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
 [Content Brief]

[2]. Zhao H, et al. Increasing L-threonine production in Escherichia coli by engineering the glyoxylate shunt and the L-threonine biosynthesis pathway. Appl Microbiol Biotechnol. 2018 Jul;102(13):5505-5518.
 [Content Brief]