Lab 170250F

• CAT Number: I030414
• CAS Number: 88630-25-5
• Molecular Formula: C17H14ClN3O
• Molecular Weight: 311.76
• Purity: 98%
• Synonyms: Lab 170250F; Lab-170250F; Lab170250F
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 1-((2-(4-chlorophenyl)-3-phenyloxiran-2-yl)methyl)-1H-1,2,4-triazole
• InChI: InChI=1S/C17H14ClN3O/c18-15-8-6-14(7-9-15)17(10-21-12-19-11-20-21)16(22-17)13-4-2-1-3-5-13/h1-9,11-12,16H,10H2
• InChIKey: YGLGKNIVFJHGIW-UHFFFAOYSA-N
• SMILES: ClC1=CC=C(C2(CN3N=CN=C3)OC2C4=CC=CC=C4)C=C1

Lab 170250F is a potent inhibitor of cytochrome P-450-obtusifoliol-14-demethylase.

Reference

1: Grausem B, Chaubet N, Gigot C, Loper JC, Benveniste P. Functional expression of Saccharomyces cerevisiae CYP51A1 encoding lanosterol-14-demethylase in tobacco results in bypass of endogenous sterol biosynthetic pathway and resistance to an obtusifoliol-14-demethylase herbicide inhibitor. Plant J. 1995 May;7(5):761-70. PubMed PMID: 7773307.
2: Maillot-Vernier P, Schaller H, Benveniste P, Belliard G. Biochemical characterization of a sterol mutant plant regenerated from a tobacco callus resistant to a triazole cytochrome-P-450-obtusifoliol-14-demethylase inhibitor. Biochem Biophys Res Commun. 1989 Nov 30;165(1):125-30. PubMed PMID: 2590214.
3: Maillot-Vernier P, Gondet L, Schaller H, Benveniste P, Belliard G. Genetic study and further biochemical characterization of a tobacco mutant that overproduces sterols. Mol Gen Genet. 1991 Dec;231(1):33-40. PubMed PMID: 1753944.