Labdane F2

• CAT Number: I030415
• CAS Number: 89900-49-2
• Molecular Formula: C20H34O
• Molecular Weight: 290.49
• Purity: 98%
• Synonyms: Labdane F2
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (1R,2S,4aR,8aR)-2,5,5,8a-tetramethyl-1-(3-methylenepent-4-en-1-yl)decahydronaphthalen-2-ol
• InChI: InChI=1S/C20H34O/c1-7-15(2)9-10-17-19(5)13-8-12-18(3,4)16(19)11-14-20(17,6)21/h7,16-17,21H,1-2,8-14H2,3-6H3/t16-,17-,19-,20+/m1/s1
• InChIKey: JTWQQJDENGGSBJ-LFGUQSLTSA-N
• SMILES: O[C@]1(C)[C@H](CCC(C=C)=C)[C@]2(C)CCCC(C)(C)[C@@]2([H])CC1

Labdane F2 is a thromboxane B2 and leukotriene B4 antagonist isolated from the Spanish herb Sideritis javalambrensis.

Reference

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2: Roengsumran S, Petsom A, Kuptiyanuwat N, Vilaivan T, Ngamrojnavanich N, Chaichantipyuth C, Phuthong S. Cytotoxic labdane diterpenoids from Croton oblongifolius. Phytochemistry. 2001 Jan;56(1):103-7. PubMed PMID: 11198816.
3: Kalpoutzakis E, Aligiannis N, Mitaku S, Chinou I, Harvala C, Skaltsounis AL. New semisynthetic antimicrobial labdane-type diterpenoids derived from the resin "ladano" of Cistus creticus. Z Naturforsch C. 2001 Jan-Feb;56(1-2):49-52. PubMed PMID: 11302213.
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6: de las Heras B, Hoult JR. Non-cytotoxic inhibition of macrophage eicosanoid biosynthesis and effects on leukocyte functions and reactive oxygen species of two novel anti-inflammatory plant diterpenoids. Planta Med. 1994 Dec;60(6):501-6. PubMed PMID: 7809200.