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36894-69-6-Labetalol Labetalol

Labetalol

For research use only. Not for therapeutic Use.

  • CAT Number: I030416
  • CAS Number: 36894-69-6
  • Molecular Formula: C19H24N2O3
  • Molecular Weight: 328.41
  • Purity: 98%
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Labetalol（Cat No.:I030416） is a medication with mixed alpha and beta-adrenergic blocking properties commonly prescribed for high blood pressure treatment. In severe hypertensive situations, it can be administered intravenously, while oral administration is suitable for long-term management. Research indicates that the pharmacokinetics of labetalol is notably influenced by common CYP2C19 polymorphisms, which can affect its metabolism. Therefore, individuals with specific genetic variations in the CYP2C19 gene may experience altered drug response or require dose adjustments when using labetalol.


Catalog Number I030416
CAS Number 36894-69-6
Synonyms

Labetalol, Normodyne, Trandate, Albetol, Apo-Labetalol, Dilevalol

Molecular Formula C19H24N2O3
Purity 98%
Target Neuronal Signaling
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 2-hydroxy-5-(1-hydroxy-2-((4-phenylbutan-2-yl)amino)ethyl)benzamide
InChI InChI=1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24)
InChIKey SGUAFYQXFOLMHL-UHFFFAOYSA-N
SMILES O=C(N)C1=CC(C(O)CNC(C)CCC2=CC=CC=C2)=CC=C1O
Reference

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2: Fischer JH, Sarto GE, Hardman J, Endres L, Jenkins TM, Kilpatrick SJ, Jeong H, Geller S, Deyo K, Fischer PA, Rodvold KA. Influence of gestational age and body weight on the pharmacokinetics of labetalol in pregnancy. Clin Pharmacokinet. 2014 Apr;53(4):373-83. doi: 10.1007/s40262-013-0123-0. PubMed PMID: 24297680; PubMed Central PMCID: PMC4310214.
3: Liu-DeRyke X, Levy PD, Parker D Jr, Coplin W, Rhoney DH. A prospective evaluation of labetalol versus nicardipine for blood pressure management in patients with acute stroke. Neurocrit Care. 2013 Aug;19(1):41-7. doi: 10.1007/s12028-013-9863-9. PubMed PMID: 23760911.
4: Chan SW, Hu M, Ko SS, Tam CW, Fok BS, Yin OQ, Chow MS, Tomlinson B. CYP2C19 genotype has a major influence on labetalol pharmacokinetics in healthy male Chinese subjects. Eur J Clin Pharmacol. 2013 Apr;69(4):799-806. doi: 10.1007/s00228-012-1428-x. Epub 2012 Oct 23. PubMed PMID: 23090703.
5: Peacock WF, Varon J, Baumann BM, Borczuk P, Cannon CM, Chandra A, Cline DM, Diercks D, Hiestand B, Hsu A, Jois-Bilowich P, Kaminski B, Levy P, Nowak RM, Schrock JW. CLUE: a randomized comparative effectiveness trial of IV nicardipine versus labetalol use in the emergency department. Crit Care. 2011;15(3):R157. doi: 10.1186/cc10289. Epub 2011 Jun 27. PubMed PMID: 21707983; PubMed Central PMCID: PMC3219031.
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11: McGuinness N, Cording V. Raynaud’s phenomenon of the nipple associated with labetalol use. J Hum Lact. 2013 Feb;29(1):17-9. doi: 10.1177/0890334412467509. Epub 2012 Dec 4. PubMed PMID: 23212937.
12: Thomas CA, Moffett BS, Wagner JL, Mott AR, Feig DI. Safety and efficacy of intravenous labetalol for hypertensive crisis in infants and small children. Pediatr Crit Care Med. 2011 Jan;12(1):28-32. doi: 10.1097/PCC.0b013e3181e328d8. PubMed PMID: 20495503.
13: Carvalho TM, Cavalli Rde C, Cunha SP, de Baraldi CO, Marques MP, Antunes NJ, Godoy AL, Lanchote VL. Influence of gestational diabetes mellitus on the stereoselective kinetic disposition and metabolism of labetalol in hypertensive patients. Eur J Clin Pharmacol. 2011 Jan;67(1):55-61. doi: 10.1007/s00228-010-0896-0. Epub 2010 Sep 17. PubMed PMID: 20848091.
14: Nooij LS, Visser S, Meuleman T, Vos P, Roelofs R, de Groot CJ. The optimal treatment of severe hypertension in pregnancy: update of the role of nicardipine. Curr Pharm Biotechnol. 2014;15(1):64-9. PubMed PMID: 24720593.
15: Labetalol and hydrochlorothiazide in hypertension. Labetalol/Hydrochlorothiazide Multicenter Study Group. Clin Pharmacol Ther. 1985 Jul;38(1):24-7. PubMed PMID: 2860990.
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