Lactacystin (Synthetic)

• CAT Number: R002306
• CAS Number: 133343-34-7
• Molecular Formula: C15H24N2O7S
• Molecular Weight: 376.42
• Purity: ≥95%
• Synonyms: N-Acetyl-S-[(3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-prolyl]-L-cysteine; Lactacystin
• Target: Metabolic Enzyme/Protease
• Solubility: Soluble to 10 mM in sterile water
• Storage: Store at -20°C
• IUPAC Name: (2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
• InChI: InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
• InChIKey: DAQAKHDKYAWHCG-RWTHQLGUSA-N
• SMILES: C[C@@H]1[C@@H]([C@](NC1=O)([C@H](C(C)C)O)C(=O)SC[C@@H](C(=O)O)NC(=O)C)O

Lactacystin (Synthetic)（Cat No.:R002306）is a potent proteasome inhibitor, often used in research to study protein degradation pathways. It selectively inhibits the 20S proteasome, an enzyme complex responsible for degrading damaged or misfolded proteins within cells. By blocking the proteasome, lactacystin can induce the accumulation of unwanted proteins, providing insight into the regulation of cellular processes such as apoptosis, cell cycle, and protein turnover. It has been used in studies related to neurodegenerative diseases, like Parkinson’s, as it may help model the accumulation of toxic proteins. However, due to its strong effects, it requires careful handling in laboratory settings.