Lalistat 1

For research use only. Not for therapeutic Use.

  • CAT Number: I015041
  • CAS Number: 501104-16-1
  • Molecular Formula: C₁₂H₁₈N₄O₃S
  • Molecular Weight: 298.36
  • Purity: ≥95%
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Lalistat 1(Cat No.:I015041)is a potent and selective inhibitor of the enzyme acyl-CoAacyltransferase 1 (ACAT1), which plays a critical role in cholesterol esterification and lipid metabolism. By inhibiting ACAT1, Lalistat 1 modulates lipid homeostasis and has been explored for its potential therapeutic effects in conditions such as atherosclerosis and metabolic disorders. It is a valuable tool in studying lipid metabolism pathways and holds promise for the development of lipid-targeted therapies in cardiovascular diseases and other metabolic conditions related to cholesterol dysregulation.


Catalog Number I015041
CAS Number 501104-16-1
Molecular Formula C₁₂H₁₈N₄O₃S
Purity ≥95%
Target Beta-lactamase
IUPAC Name (4-piperidin-1-yl-1,2,5-thiadiazol-3-yl) morpholine-4-carboxylate
InChI InChI=1S/C12H18N4O3S/c17-12(16-6-8-18-9-7-16)19-11-10(13-20-14-11)15-4-2-1-3-5-15/h1-9H2
InChIKey XAWUWPUYJUOUOF-UHFFFAOYSA-N
SMILES C1CCN(CC1)C2=NSN=C2OC(=O)N3CCOCC3
Reference

[1]. Anton I Rosenbaum , et al. Thiadiazole carbamates: potent inhibitors of lysosomal acid lipase and potential Niemann-Pick type C disease therapeutics. J Med Chem . 2010 Jul 22;53(14):5281-9.<br>[2]. Livia Shehaj, et al. Small-Molecule Inhibitors of Haemophilus influenzae IgA1 Protease.ACS Infect Dis. 2019 Jul 12;5(7):1129-1138.

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