For research use only. Not for therapeutic Use.
LANA-DNA-IN-1 is a potent LANA-DNA inhibitor. LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM. LANA-DNA-IN-1shows against wild-type LANA with IC50 value of 53 μM. LANA-DNA-IN-1 can be used for the research of infection[1].
LANA-DNA-IN-1 has inhibition activity for LBS2, LBS1 and LBS3 with IC50 values of 8 μM, 9μM and 8μM in FP Assay[1].
LANA-DNA-IN-1 has potent LANA-LBS1-inhibitory with an IC50 values of 53 μM[1].
LANA-DNA-IN-1 (31.25, 62.5, 125 and 250 μM) has potent against wild-type LANA CTD and the oligomerization-deficient LANA DBD mutant[1].
| Catalog Number | I042856 |
| CAS Number | 2512847-06-0 |
| Synonyms | 4-[1-(6-methylisoquinolin-4-yl)triazol-4-yl]benzoic acid |
| Molecular Formula | C19H14N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H14N4O2/c1-12-2-3-15-9-20-10-18(16(15)8-12)23-11-17(21-22-23)13-4-6-14(7-5-13)19(24)25/h2-11H,1H3,(H,24,25) |
| InChIKey | IUUGYORBUIOUSZ-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=NC=C2C=C1)N3C=C(N=N3)C4=CC=C(C=C4)C(=O)O |
| Reference | [1]. Philine Kirsch, et al. Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi’s sarcoma-associated herpesvirus infections. Eur J Med Chem. 2020 Sep 15;202:112525 |
