Lanicemine dihydrochloride

• CAT Number: I030473
• CAS Number: 153322-06-6
• Molecular Formula: C13H16Cl2N2
• Molecular Weight: 271.18
• Purity: 98%
• Synonyms: ARL-15896AR; AZD-6765 dihydrochloride; FPL-15896AR; Lanicemine dihydrochloride; Lanicemine 2HCl
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-Pyridineethanamine, alpha-phenyl-, (alphaS)-, dihydrochloride
• InChI: InChI=1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1
• InChIKey: KHJHFYAGQZYCLC-GXKRWWSZSA-N
• SMILES: Cl.Cl.N[C@@H](Cc1ccccn1)c2ccccc2

Lanicemine dihydrochloride (Cat.No:I030473) is a novel dissociative anesthetic agent that acts as a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist. It has shown promise in preclinical and clinical studies for the treatment of depression and other psychiatric disorders. Lanicemine is being investigated for its potential antidepressant and neuroprotective effects, with a focus on its rapid onset of action and prolonged antidepressant effects.

Reference

1: Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, Lodge D, Halberstadt AL, Brandt SD, Adejare A. Pharmacological Investigations of the Dissociative ‘Legal Highs’ Diphenidine, Methoxphenidine and Analogues. PLoS One. 2016 Jun 17;11(6):e0157021. doi: 10.1371/journal.pone.0157021. eCollection 2016. PubMed PMID: 27314670; PubMed Central PMCID: PMC4912077.
2: Downey D, Dutta A, McKie S, Dawson GR, Dourish CT, Craig K, Smith MA, McCarthy DJ, Harmer CJ, Goodwin GM, Williams S, Deakin JF. Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate. Eur Neuropsychopharmacol. 2016 Jun;26(6):994-1003. doi: 10.1016/j.euroneuro.2016.03.006. Epub 2016 Apr 28. PubMed PMID: 27133029.
3: Keavy D, Bristow LJ, Sivarao DV, Batchelder M, King D, Thangathirupathy S, Macor JE, Weed MR. The qEEG Signature of Selective NMDA NR2B Negative Allosteric Modulators; A Potential Translational Biomarker for Drug Development. PLoS One. 2016 Apr 1;11(4):e0152729. doi: 10.1371/journal.pone.0152729. eCollection 2016. PubMed PMID: 27035340; PubMed Central PMCID: PMC4817977.