Laninamivir Octanoate Monohydrate

• CAT Number: I007615
• CAS Number: 1233643-88-3(Monohydrate); 203120-46-1(free)
• Molecular Formula: C21H38N4O9
• Molecular Weight: 490.55
• Purity: ≥95%
• Synonyms: Laninamivir Octanoate Monohydrate; CS-8958; CS 8958; CS8958; Inavir;(2R,3R,4S)-3-acetamido-4-guanidino-2-((1R,2R)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl)-3,4-dihydro-2H-pyran-6-carboxylic acid hydrate
• Target: Influenza Virus
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-2-hydroxy-1-methoxy-3-octanoyloxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid;hydrate
• InChI: InChI=1S/C21H36N4O8.H2O/c1-4-5-6-7-8-9-16(28)32-11-14(27)18(31-3)19-17(24-12(2)26)13(25-21(22)23)10-15(33-19)20(29)30;/h10,13-14,17-19,27H,4-9,11H2,1-3H3,(H,24,26)(H,29,30)(H4,22,23,25);1H2/t13-,14+,17+,18+,19+;/m0./s1
• InChIKey: IBFFAVWCRFPPNZ-QZAMVOJNSA-N
• SMILES: CCCCCCCC(=O)OC[C@H]([C@H]([C@H]1[C@@H]([C@H](C=C(O1)C(=O)O)N=C(N)N)NC(=O)C)OC)O.O

Laninamivir octanoate monohydrate（Cat No.:I007615）is a prodrug of laninamivir, an antiviral medication used to treat and prevent influenza. It belongs to the class of neuraminidase inhibitors, which block the enzyme neuraminidase on the surface of the influenza virus, preventing the release of new viral particles and halting the spread of infection. Laninamivir octanoate is administered via inhalation, offering direct delivery to the lungs, where it exerts its antiviral effects. This form of laninamivir has shown efficacy in treating both seasonal and pandemic strains of influenza, with a generally favorable safety profile.

Reference

1: Kashiwagi S, Watanabe A, Ikematsu H, Uemori M, Awamura S; Laninamivir Prophylaxis Study Group. Long-acting Neuraminidase Inhibitor Laninamivir Octanoate as Post-exposure Prophylaxis for Influenza. Clin Infect Dis. 2016 Aug 1;63(3):330-7. doi: 10.1093/cid/ciw255. Epub 2016 Apr 26. PubMed PMID: 27118785; PubMed Central PMCID: PMC4946013.2: Ikematsu H, Kawai N, Iwaki N, Kashiwagi S. Clinical outcome of laninamivir octanoate hydrate for influenza in the 2013-2014 Japanese season. J Infect Chemother. 2015 Nov;21(11):802-7. doi: 10.1016/j.jiac.2015.08.013. Epub 2015 Sep 26. PubMed PMID: 26410550.