Lansoprazole

• CAT Number: A000492
• CAS Number: 103577-45-3
• Molecular Formula: C16H14F3N3O2S
• Molecular Weight: 369.4
• Purity: ≥95%
• Synonyms: 103577-45-3; Prevacid; Bamalite; Monolitum; Agopton
• Target: Proton Pump
• Solubility: >18.5mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
• InChIKey: MJIHNNLFOKEZEW-UHFFFAOYSA-N
• SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F

Lansoprazole is a proton-pump inhibitor (PPI) in the same pharmacologic class as omeprazole which inhibits the stomach/’s production of gastric acids. As of 2015, laboratory studies were underway on analogs of lansoprazole to explore their use as potential PET imaging agents for diagnosing tauopathies including Alzheimer/’s disease. Lansoprazole is also a prodrug that targets the cytochrome bc1 complex of Mycobacterium tuberculosis once converted to lansoprazole sulfide in mycobacterial host cells.

Reference

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